PNU 282987 ( PNU-282987; PNU 282987 )

Catalog No. M17898 CAS No. 123464-89-1

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Datasheet

HNMR

HPLC

MSDS

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Product Name

PNU 282987
Note

Research use only, not for human use.
Brief Description

PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM).
Description

PNU-282987 is a highly selective α7 nAChR agonist (Ki = 26 nM) displaying negligible blockade of α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM). PNU-282987 is inactive against a panel of 32 receptors at 1 μM, except 5-HT3 receptors (Ki = 930 nM).
Synonyms

PNU-282987; PNU 282987
Pathway

Endocrinology/Hormones
Target

AChR
Recptor

α7 nAChR
Research Area

Neurological Disease
Indication

——

CAS Number

123464-89-1
Formula Weight

301.21
Molecular Formula

C14H18Cl2N2O
Purity

98%
Solubility

DMSO : ≥ 61 mg/mL 202.52 mM; H2O : 50 mg/mL 166.00 mM;
SMILES

Cl.C1CN2CCC1[C@H](C2)NC(=O)c1ccc(cc1)Cl
Chemical Name

Benzamide, N-(3R)-1-azabicyclo(2.2.2)oct-3-yl-4-chloro-, hydrochloride (1:1)

1. Bodnar AL, et al. J Med Chem. 2005 Feb 24;48(4):905-8.

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